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An atlas of single-cell eQTLs dissects autoimmune disease genes and identifies novel drug classes for treatment

29 Mar 2025

Abstract excerpt

Most variants identified from genome-wide association studies (GWASs) are non-coding and regulate gene expression. However, many risk loci fail to colocalize with expression quantitative trait loci (eQTLs), potentially due to limited GWAS and eQTL analysis power or cellular heterogeneity. Population-scale single-cell RNA-sequencing (scRNA-seq) datasets are emerging, enabling mapping of eQTLs in different cell...

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PMID: 40154479
DOI: 10.1016/j.xgen.2025.100820

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