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An atlas of single-cell eQTLs dissects autoimmune disease genes and identifies novel drug classes for treatment.

Cell genomics - 9 Apr 2025

Wang Lida, Markus Havell, Chen Dieyi, Chen Siyuan, Zhang Fan, Gao Shuang, Khunsriraksakul Chachrit, Chen Fang, Olsen Nancy, Foulke Galen, Jiang Bibo, Carrel Laura, Liu Dajiang J

Abstract excerpt

Most variants identified from genome-wide association studies (GWASs) are non-coding and regulate gene expression. However, many risk loci fail to colocalize with expression quantitative trait loci (eQTLs), potentially due to limited GWAS and eQTL analysis power or cellular heterogeneity. Population-scale single-cell RNA-sequencing (scRNA-seq) datasets are emerging, enabling mapping of eQTLs in different cell...

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Identifiers

PMID: 40154479
DOI: 10.1016/j.xgen.2025.100820
PMCID: PMC12008810

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