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Article

The impact of cell type and context-dependent regulatory variants on human immune traits.

Genome biology - 29 Apr 2021

Mu Zepeng, Wei Wei, Fair Benjamin, Miao Jinlin, Zhu Ping, Li Yang I

Abstract excerpt

BACKGROUND: The vast majority of trait-associated variants identified using genome-wide association studies (GWAS) are noncoding, and therefore assumed to impact gene regulation. However, the majority of trait-associated loci are unexplained by regulatory quantitative trait loci (QTLs). RESULTS: We perform a comprehensive characterization of the putative mechanisms by which GWAS loci impact human immune traits....

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Identifiers

PMID: 33926512
DOI: 10.1186/s13059-021-02334-x
PMCID: PMC8082814

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