Article

AAV-deliverable hypercompact adenine base editors based on transposase B guided by engineered RNA

2022-04-12

Abstract excerpt

Transposon-associated transposase B (TnpB) is deemed an ancestral protein for type V, Cas12 family members, and the closest ancestor to UnCas12f1 due to its high sequence similarity. Previously, we reported a set of engineered guide RNAs supporting high indel efficiency for Cas12f1 in human cells. Here, we suggest a new technology whereby the engineered gRNAs also manifest highly efficiency programmable endonuclea...

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Literature Corpus work: f9961ce6-4403-50bf-90b7-52a5ca6ab6bc
DOI: 10.21203/rs.3.rs-1326630/v1

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