Article

A single CRISPR base editor to induce simultaneous C-to-T and A-to-G mutations

2019-08-08

Abstract excerpt

While several Cas9-derived base editors have been developed to induce either C-to-T or A-to-G mutation at target genomic sites, the possible genome editing space when using the current base editors remains limited. Here, we present a novel base editor, Target-ACE, which integrates the abilities of both of the previously developed C-to-T and A-to-G base editors by fusing an activation-induced cytidine deaminase (AI...

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Identifiers and source

Literature Corpus work: 3a8c3501-bdff-54ff-8f3c-43189d5fd49a
DOI: 10.1101/729269

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