Article

A Cas-Embedding Strategy for Minimizing Off-Target Effects of DNA Base Editors

2020-07-24

Abstract excerpt

<title>Abstract</title> <p>DNA base editors, typically comprising editing enzymes fused to the N-terminus of nCas9, display off-target effects on DNA and/or RNA, which have remained a obstacle to their clinical applications. Off-target edits are typically countered via rationally designed point mutations, but the approach is tedious and not always effective. Here, we report that the off-target effects of both A>G...

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Literature Corpus work: 8e719ae3-fe21-542c-84dd-ee38c8f7f91c
DOI: 10.21203/rs.3.rs-46265/v1

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