Article
REPAIRx, a specific yet highly efficient programmable A > I RNA base editor.
The EMBO journal - 16 Nov 2020
Liu Yajing, Mao Shaoshuai, Huang Shisheng, Li Yongqin, Chen Yuxin, Di Minghui, Huang Xinxin, Lv Junjun, Wang Xinxin, Ge Jianyang, Shen Shengxi, Zhang Xiaoming, Liu Dahai, Huang Xingxu, Chi Tian
Abstract excerpt
Programmable A > I RNA editing is a valuable tool for basic research and medicine. A variety of editors have been created, but a genetically encoded editor that is both precise and efficient has not been described to date. The trade-off between precision and efficiency is exemplified in the state of the art editor REPAIR, which comprises the ADAR2 deaminase domain fused to dCas13b. REPAIR is highly efficient, but...
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