Article

Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

2019-09-09

Abstract excerpt

It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical antidepressant effect. We discovered that the transmembrane domain of TRKB, the brain-derived neurotrophic factor (BDNF) receptor that promotes neuronal plasticity and antidepressant responses, has a cholesterol-sensing function that mediates synaptic effects of cholesterol. We then found that both typical and fast-acting...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f98a9631-2693-5877-8627-9be51a4ce643
DOI: 10.1101/757989

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Antidepressant drugs act by directly binding to TRKB neurotrophin receptorsDOI 10.1101/757989Read

International Union of Basic and Clinical Pharmacology CIV: The Neurobiology of Treatment-resistant Depression: From Antidepressant Classifications to Novel Pharmacological Targets.Semantic proximity Read

Mutation in the TRKB Cholesterol Recognition Site that blocks Antidepressant Binding does not Influence the Basal or BDNF-Stimulated Activation of TRKB.Semantic proximity Read

HBK-15 bypasses BDNF via ERK1/2-biased 5-HT1A receptor signaling to deliver a rapid antidepressant-like effectSemantic proximity Read

A synaptic locus for TrkB signaling underlying ketamine rapid antidepressant actionSemantic proximity Read

Homology modeling and Structural docking analysis on a human BDNF gene by using Computational algorithmsSemantic proximity Read

Mutational and in silico analyses for antidepressant block of astroglial inward-rectifier Kir4.1 channel.Semantic proximity Read

Npbwr1 signaling mediates fast antidepressant actionSemantic proximity Read

Antidepressants interact with sex steroid receptors and their intracellular signaling componentsSemantic proximity Read

<i>Npbwr1</i> signaling mediates fast antidepressant actionSemantic proximity Read

Cholesterol binding to a conserved site modulates the conformation, pharmacology, and transport kinetics of the human serotonin transporter.Semantic proximity Read

BDNF controls cognitive processes related to neuropsychiatric manifestations via autophagic regulation of p62 and GABA <sub>A</sub> receptor traffickingSemantic proximity Read

Cell biology of BDNF and its relevance to schizophrenia.Semantic proximity Read