Article

Antidepressants interact with sex steroid receptors and their intracellular signaling components

2026-03-19

Abstract excerpt

There is growing interest in understanding how hormonal signaling pathways contribute to the pathophysiology of mood disorders, based on the premise that fluctuations in sex hormones influence mood, a relationship particularly evident in conditions such as premenstrual dysphoric disorder, prenatal depression, postpartum depression, and perimenopausal depression. Estrogen receptor alpha (ERα) is predominantly local...

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Literature Corpus work: be8f299c-04cc-5838-a906-33b3b17da4f7
DOI: 10.64898/2026.03.17.712321

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