Article
Cholesterol binding to a conserved site modulates the conformation, pharmacology, and transport kinetics of the human serotonin transporter.
The Journal of biological chemistry - 9 Mar 2018
Laursen Louise, Severinsen Kasper, Kristensen Kristina Birch, Periole Xavier, Overby Malene, Müller Heidi Kaastrup, Schiøtt Birgit, Sinning Steffen
Abstract excerpt
The serotonin transporter (SERT) is important for reuptake of the neurotransmitter serotonin from the synaptic cleft and is also the target of most antidepressants. It has previously been shown that cholesterol in the membrane bilayer affects the conformation of SERT. Although recent crystal structures have identified several potential cholesterol-binding sites, it is unclear whether any of these potential...
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