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Article

Mutation in the TRKB Cholesterol Recognition Site that blocks Antidepressant Binding does not Influence the Basal or BDNF-Stimulated Activation of TRKB.

Cellular and molecular neurobiology - 17 Dec 2023

Biojone Caroline, Cannarozzo Cecilia, Seiffert Nina, Diniz Cassiano R A F, Brunello Cecilia A, Castrén Eero, Casarotto Plinio

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) acting upon its receptor Neurotrophic tyrosine kinase receptor 2 (NTRK2, TRKB) plays a central role in the development and maintenance of synaptic function and activity- or drug-induced plasticity. TRKB possesses an inverted cholesterol recognition and alignment consensus sequence (CARC), suggesting this receptor can act as a cholesterol sensor. We have recently shown that...

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Identifiers

PMID: 38104054
DOI: 10.1007/s10571-023-01438-1
PMCID: PMC10725331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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