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Article

A synaptic locus for TrkB signaling underlying ketamine rapid antidepressant action

1 Aug 2021

Abstract excerpt

Ketamine produces rapid antidepressant action in patients with major depression or treatment-resistant depression. Studies have identified brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin receptor kinase B (TrkB), as necessary for the antidepressant effects and underlying ketamine-induced synaptic potentiation in the hippocampus. Here, we delete BDNF or TrkB in presynaptic CA3 or...

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PMID: 34407417
DOI: 10.1016/j.celrep.2021.109513

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