Article

BDNF controls cognitive processes related to neuropsychiatric manifestations via autophagic regulation of p62 and GABA <sub>A</sub> receptor trafficking

2018-05-30

Abstract excerpt

<h4>Summary</h4> Reduced BDNF and GABAergic inhibition co-occur in neuropsychiatric diseases, including major depression. Genetic rodent studies show a causal link, suggesting the presence of biological pathways that mediate this co-occurrence. Here we show that mice with reduced Bdnf ( Bdnf +/- ) have upregulated expression of sequestosome-1/p62, an autophagy-associated stress response protein, and reduced surf...

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Literature Corpus work: 2914b808-d83b-5ba1-9078-e99a8634391d
DOI: 10.1101/334466

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