Article
International Union of Basic and Clinical Pharmacology CIV: The Neurobiology of Treatment-resistant Depression: From Antidepressant Classifications to Novel Pharmacological Targets.
Pharmacological reviews - 1 Jul 2018
Caraci F, Calabrese F, Molteni R, Bartova L, Dold M, Leggio G M, Fabbri C, Mendlewicz J, Racagni G, Kasper S, Riva M A, Drago F
Abstract excerpt
Major depressive disorder is one of the most prevalent and life-threatening forms of mental illnesses and a major cause of morbidity worldwide. Currently available antidepressants are effective for most patients, although around 30% are considered treatment resistant (TRD), a condition that is associated with a significant impairment of cognitive function and poor quality of life. In this respect, the...
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