Article

HBK-15 bypasses BDNF via ERK1/2-biased 5-HT1A receptor signaling to deliver a rapid antidepressant-like effect

2025-08-28

Abstract excerpt

<title>Abstract</title> <p> Rapid-onset antidepressants hold transformative potential for treating affective and cognitive symptoms of depression, yet their mechanisms remain incompletely understood. Serotonin receptors orchestrate emotional and cognitive regulation, but current treatments poorly target their intracellular signaling. Here, we characterize HBK-15, a multi-target aminergic ligand, as a functionall...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 479fcaf5-75f4-5b01-b30f-b003be49f567
DOI: 10.21203/rs.3.rs-7315313/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HBK-15 bypasses BDNF via ERK1/2-biased 5-HT1A receptor signaling to deliver a rapid antidepressant-like effectDOI 10.21203/rs.3.rs-7315313/v1Read

( <i>2R,6R</i> )-hydroxynorketamine facilitates extinction and prevents emotional impairment and stress-induced reinstatement in morphine abstinent miceSemantic proximity Read

International Union of Basic and Clinical Pharmacology CIV: The Neurobiology of Treatment-resistant Depression: From Antidepressant Classifications to Novel Pharmacological Targets.Semantic proximity Read

Ketamine induces synaptic and monoaminergic remodeling in human iPSC-derived neuronsSemantic proximity Read

Npbwr1 signaling mediates fast antidepressant actionSemantic proximity Read

<i>Npbwr1</i> signaling mediates fast antidepressant actionSemantic proximity Read

BDNF controls cognitive processes related to neuropsychiatric manifestations via autophagic regulation of p62 and GABA <sub>A</sub> receptor traffickingSemantic proximity Read

Kappa Opioid Receptor Activation Induces Epigenetic Silencing of Brain-Derived Neurotropic Factor via HDAC5 in DepressionSemantic proximity Read

The ability of BDNF to modify neurogenesis and depressive-like behaviors is dependent upon phosphorylation of tyrosine residues 365/367 in the GABA(A)-receptor γ2 subunit.Semantic proximity Read

Serotonin 1A receptor-mediated signaling through ERK and PKCα is essential for normal synaptogenesis in neonatal mouse hippocampus.Semantic proximity Read

Antidepressant drugs act by directly binding to TRKB neurotrophin receptorsSemantic proximity Read

Kappa opioid receptor activation induces epigenetic silencing of brain-derived neurotropic factor via HDAC5 in depressionSemantic proximity Read

Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenulaSemantic proximity Read