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APOE Genotype Influences on The Brain Metabolome of Aging Mice – Role for Mitochondrial Energetics in Mechanisms of Resilience in APOE2 Genotype

2025-03-01

Abstract excerpt

Alzheimer’s disease (AD) risk and progression are significantly influenced by APOE genotype with APOE4 increasing and APOE2 decreasing susceptibility compared to APOE3. While the effect of those genotypes was extensively studied on blood metabolome, less is known about their impact in the brain. Here we investigated the impacts of APOE genotypes and aging on brain metabolic profiles across the lifespan, using huma...

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Literature Corpus work: 1e0cb9e5-d58a-5f30-8464-908e541ac613
DOI: 10.1101/2025.02.25.640178

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