Article

APOE4 Accelerates Menopause-Associated Brain Metabolic Shift and Disrupts Bioenergetic Adaptation

2026-03-14

Abstract excerpt

<h4>Introduction</h4> Disruption of brain glucose and lipid metabolism contributes to Alzheimer’s disease (AD) and often emerges before clinical symptoms. Women are at elevated AD risk due to menopause-associated estrogen decline, which impairs mitochondrial function and glucose metabolism. Women’s risk of AD is further elevated by the APOE4 allele, the strongest genetic risk factor for late-onset AD. <h4>Methods...

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Literature Corpus work: a26230c1-26a5-5aa5-9e55-4fcd663dffce
DOI: 10.64898/2026.03.11.710133

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