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Article

APOE genotype influences on the brain metabolome of aging mice - role for mitochondrial energetics in mechanisms of resilience in APOE2 genotype.

Molecular neurodegeneration - 2 Sept 2025

Borkowski Kamil, Liang Nuanyi, Zhao Na, Arnold Matthias, Huynh Kevin, Karu Naama, Mahmoudiandehkordi Siamak, Kueider-Paisley Alexandra, Kanekiyo Takahisa, Bu Guojun, Kaddurah-Daouk Rima

Abstract excerpt

Alzheimer’s disease (AD) risk and progression are significantly influenced by APOE genotype with APOE4 increasing and APOE2 decreasing susceptibility compared to APOE3. While the effect of those genotypes was extensively studied on blood metabolome, less is known about their impact in the brain. Here we investigated the impacts of APOE genotypes and aging on brain metabolic profiles across the lifespan, using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40898377
DOI: 10.1186/s13024-025-00888-z
PMCID: PMC12403941

Genes

APOE
C5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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