Article

DISC1 regulates N-Methyl-D-Aspartate receptor dynamics: Abnormalities induced by a <i>Disc1</i> mutation modelling a translocation linked to major mental illness

2018-06-17

Abstract excerpt

<h4>ABSTRACT</h4> The neuromodulatory gene DISC1 is disrupted by a t(1;11) translocation that is highly penetrant for schizophrenia and affective disorders, but how this translocation affects DISC1 function is incompletely understood. N-Methyl-D-Aspartate receptors (NMDAR) play a central role in synaptic plasticity and cognition, and are implicated in the pathophysiology of schizophrenia through genetic and func...

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Literature Corpus work: f91f8325-9460-5317-9db5-ca868c058c26
DOI: 10.1101/349365

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