Article

DISC1, differential expression, and deconvolution : human and mouse RNA-Seq investigation of a t(1;11) translocation that predisposes to major mental illness

2020-01-01

Abstract excerpt

The t(1;11) translocation is a mutation unique to a Scottish pedigree, members of which have been diagnosed with schizophrenia, bipolar disorder, recurrent major depressive disorder and other related disorders. The translocation is significantly linked to increased risk of these diagnoses. It disrupts three genes, only one of which, DISC1, encodes a protein. A number of experiments have explored the function of DI...

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Literature Corpus work: 2a769aaf-ce4c-57c9-8348-7219e05e844e
DOI: 10.7488/era/217

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