Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial trafficking

2 Oct 2013

Abstract excerpt

Disrupted-In-Schizophrenia 1 (DISC1) is a candidate risk factor for schizophrenia, bipolar disorder and severe recurrent depression. Here, we demonstrate that DISC1 associates robustly with trafficking-protein-Kinesin-binding-1 which is, in turn, known to interact with the outer mitochondrial membrane proteins Miro1/2, linking mitochondria to the kinesin motor for microtubule-based subcellular trafficking. DISC1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Cholinesterase and Neurodegenerative Diseases
Share to Phosphodiesterase function and regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24092329
DOI: 10.1093/hmg/ddt485

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial traffickingPMID 24092329Read ↗

Mitochondrial roles of the psychiatric disease risk factor DISC1.Semantic proximity Read ↗

DISC1 Regulates Mitochondrial Trafficking in a Miro1-GTP-Dependent MannerSemantic proximity Read ↗

Regulation of mitochondrial dynamics by DISC1, a putative risk factor for major mental illness.Semantic proximity Read ↗

DISC1 regulates N-methyl-D-aspartate receptor dynamics: abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness.Semantic proximity Read ↗

Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondriaSemantic proximity Read ↗

DISCopathies: brain disorders related to DISC1 dysfunction.Semantic proximity Read ↗

Understanding the role of DISC1 in psychiatric disease and during normal development.Semantic proximity Read ↗

DISC1 regulates N-Methyl-D-Aspartate receptor dynamics: Abnormalities induced by a <i>Disc1</i> mutation modelling a translocation linked to major mental illnessSemantic proximity Read ↗

Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site.Semantic proximity Read ↗

Disrupted-in-Schizophrenia-1.Semantic proximity Read ↗

How has DISC1 enabled drug discovery?Semantic proximity Read ↗

Disrupted in schizophrenia 1 (DISC1): subcellular targeting and induction of ring mitochondria.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.