Article
DISC1 regulates N-methyl-D-aspartate receptor dynamics: abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness.
Translational psychiatry - 6 Sept 2018
Malavasi Elise L V, Economides Kyriakos D, Grünewald Ellen, Makedonopoulou Paraskevi, Gautier Philippe, Mackie Shaun, Murphy Laura C, Murdoch Hannah, Crummie Darragh, Ogawa Fumiaki, McCartney Daniel L, O'Sullivan Shane T, Burr Karen, Torrance Helen S, Phillips Jonathan, Bonneau Marion, Anderson Susan M, Perry Paul, Pearson Matthew, Constantinides Costas, Davidson-Smith Hazel, Kabiri Mostafa, Duff Barbara, Johnstone Mandy, Polites H Greg, Lawrie Stephen M, Blackwood Douglas H, Semple Colin A, Evans Kathryn L, Didier Michel, Chandran Siddharthan, McIntosh Andrew M, Price David J, Houslay Miles D, Porteous David J, Millar J Kirsty
Abstract excerpt
The neuromodulatory gene DISC1 is disrupted by a t(1;11) translocation that is highly penetrant for schizophrenia and affective disorders, but how this translocation affects DISC1 function is incompletely understood. N-methyl-D-aspartate receptors (NMDAR) play a central role in synaptic plasticity and cognition, and are implicated in the pathophysiology of schizophrenia through genetic and functional studies. We...
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