Article

The H3.3 K36M oncohistone disrupts the establishment of epigenetic memory through loss of DNA methylation

2023-10-14

Abstract excerpt

<h4>Summary</h4> Histone H3.3 is frequently mutated in cancers, with the lysine 36 to methionine mutation (K36M) being a hallmark of chondroblastomas. While it is known that H3.3K36M changes the cellular epigenetic landscape, it remains unclear how it affects the dynamics of gene expression. Here, we use a synthetic reporter to measure the effect of H3.3K36M on silencing and epigenetic memory after recruitment of...

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Literature Corpus work: f904f076-d6d0-5770-a880-50d1004537d9
DOI: 10.1101/2023.10.13.562147

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