Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation.

Proceedings of the National Academy of Sciences of the United States of America - 2 Mar 2021

Rajagopalan Kartik N, Chen Xiao, Weinberg Daniel N, Chen Haifen, Majewski Jacek, Allis C David, Lu Chao

Abstract excerpt

Hotspot histone H3 mutations have emerged as drivers of oncogenesis in cancers of multiple lineages. Specifically, H3 lysine 36 to methionine (H3K36M) mutations are recurrently identified in chondroblastomas, undifferentiated sarcomas, and head and neck cancers. While the mutation reduces global levels of both H3K36 dimethylation (H3K36me2) and trimethylation (H3K36me3) by dominantly inhibiting their respective...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimetabolites, Antineoplastic
Share to Carcinogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytarabine

Share to Decitabine

Share to Gene Editing

Share to Histone-Lysine N-Methyltransferase

Share to Mesenchymal Stem Cells

Share to Methylation

Source

Open in PubMed Open full text

Identifiers

PMID: 33619101
DOI: 10.1073/pnas.2021795118
PMCID: PMC7936350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation.PMID 33619101Read ↗

The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas.Semantic proximity Read ↗

Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape.Semantic proximity Read ↗

H3K36 Methylation - a Guardian of Epigenome IntegritySemantic proximity Read ↗

The H3.3K36M oncohistone disrupts the establishment of epigenetic memory through loss of DNA methylation.Semantic proximity Read ↗

A histone H3.3K36M mutation in mice causes an imbalance of histone modifications and defects in chondrocyte differentiation.Semantic proximity Read ↗

Systematic perturbations of SETD2, NSD1, NSD2, NSD3 and ASH1L reveals their distinct contributions to H3K36 methylationSemantic proximity Read ↗

The H3.3 K36M oncohistone disrupts the establishment of epigenetic memory through loss of DNA methylationSemantic proximity Read ↗

Oncohistone interactome profiling uncovers contrasting oncogenic mechanisms and identifies potential therapeutic targets in high grade glioma.Semantic proximity Read ↗

Probe the function of histone lysine 36 methylation using histone H3 lysine 36 to methionine mutant transgene in mammalian cells.Semantic proximity Read ↗

Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression.Semantic proximity Read ↗

Histone Mutations and Bone Cancers.Semantic proximity Read ↗

Recognition of cancer mutations in histone H3K36 by epigenetic writers and readers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.