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Article

A histone H3.3K36M mutation in mice causes an imbalance of histone modifications and defects in chondrocyte differentiation.

Epigenetics - 1 Oct 2021

Abe Shusaku, Nagatomo Hiroaki, Sasaki Hiroyuki, Ishiuchi Takashi

Abstract excerpt

Histone lysine-to-methionine (K-to-M) mutations have been identified as driver mutations in human cancers. Interestingly, these 'oncohistone' mutations inhibit the activity of histone methyltransferases. Therefore, they can potentially be used as versatile tools to investigate the roles of histone modifications. In this study, we generated a genetically engineered mouse line in which an H3.3K36M mutation could be...

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Identifiers

PMID: 33135541
DOI: 10.1080/15592294.2020.1841873
PMCID: PMC8510613

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A histone H3.3K36M mutation in mice causes an imbalance of histone modifications and defects in chondrocyte differentiation.PMID 33135541Read ↗

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