Article
The H3.3 G34W oncohistone mutation increases K36 methylation by the protein lysine methyltransferase NSD1.
Biochimie - 1 Jul 2022
Bröhm Alexander, Schoch Tabea, Grünberger David, Khella Mina S, Schuhmacher Maren Kirstin, Weirich Sara, Jeltsch Albert
Abstract excerpt
The H3.3 G34W mutation has been observed in 90% of the patients affected by giant cell tumor of bone (GCTB). It had been shown to reduce the activity of the SETD2 H3K36 protein lysine methyltransferase (PKMT) and lead to genome wide changes in epigenome modifications including a global reduction in DNA methylation. Here, we investigated the effect of the H3.3 G34W mutation on the activity of the H3K36me2...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.