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Article

The H3.3K36M oncohistone disrupts the establishment of epigenetic memory through loss of DNA methylation.

Molecular cell - 17 Oct 2024

Sinha Joydeb, Nickels Jan F, Thurm Abby R, Ludwig Connor H, Archibald Bella N, Hinks Michaela M, Wan Jun, Fang Dong, Bintu Lacramioara

Abstract excerpt

Histone H3.3 is frequently mutated in tumors, with the lysine 36 to methionine mutation (K36M) being a hallmark of chondroblastomas. While it is known that H3.3K36M changes the epigenetic landscape, its effects on gene expression dynamics remain unclear. Here, we use a synthetic reporter to measure the effects of H3.3K36M on silencing and epigenetic memory after recruitment of the ZNF10 Krüppel-associated box...

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Share to Acetylation
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Neoplastic

Share to Histones

Share to Lysine

Share to Repressor Proteins

Source

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Identifiers

PMID: 39368466
DOI: 10.1016/j.molcel.2024.09.015
PMCID: PMC11526022

Genes

ZNF10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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