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Article

Stalling out chromatin machinery-Oncohistone mutation disrupts heterochromatin memory.

Molecular cell - 17 Oct 2024

Wasserman Sara R, Hathaway Nathaniel A

Abstract excerpt

In this issue, Sinha et al.1 use cellular chromatin reporter assays along with CRISPR gene editing to reveal that the histone H3.3K36M oncohistone mutation disrupts epigenetic memory and stability of H3K9me3 domains by blocking transitions into a stably repressed state.

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Identifiers

PMID: 39423792
DOI: 10.1016/j.molcel.2024.09.028
PMCID: PMC12009143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 11 Sept 2026.

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