Article

An ASXL3–thyroid hormone axis in parvalbumin interneurons controls autism-like behaviors

2026-05-24

Abstract excerpt

Pathogenic variants in ASXL3 underlie autism spectrum disorder (ASD), but how they perturb neural circuits and whether defects are reversible remain unclear. Here we show that Asxl3 haploinsufficiency in mice reduces cortical thickness and upper-layer projection neurons while increasing parvalbumin (PV) interneuron density and producing ASD-like behavioral abnormalities. Mechanistically, Asxl3 loss derepresses...

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Literature Corpus work: f8b8cbf6-0d67-56ee-ad18-bf70a3e02846
DOI: 10.64898/2026.05.22.727319

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