Article

ASXL3 controls cortical neuron fate specification through extrinsic self-renewal pathways

2021-07-21

Abstract excerpt

<h4>ABSTRACT</h4> During corticogenesis, transcription plasticity is fundamental to the restriction of neural progenitor cell (NPC) multipotency and production of cortical neuron heterogeneity. Human and mouse genetic studies have highlighted the role of Polycomb transcriptional regulation in this process. ASXL3 , which encodes a component of the Polycomb repressive deubiquitination (PR-DUB) complex, has been id...

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Literature Corpus work: b844e9a3-20fb-5438-adb6-d3e5af4afd33
DOI: 10.1101/2021.07.20.452995

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