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Article

Haploinsufficiency of intraflagellar transport protein 172 causes autism-like behavioral phenotypes in mice through BDNF.

Journal of advanced research - 1 Jul 2025

Zheng Nanxi, Luo Shilin, Zhang Xin, Hu Ling, Huang Muzhi, Li Mingyu, McCaig Colin, Ding Yu-Qiang, Lang Bing

Abstract excerpt

INTRODUCTION: Primary cilia are hair-like solitary organelles growing on most mammalian cells that play fundamental roles in embryonic patterning and organogenesis. Defective cilia often cause a suite of inherited diseases called ciliopathies with multifaceted manifestations. Intraflagellar transport (IFT), a bidirectional protein trafficking along the cilium, actively facilitates the formation and absorption of...

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Source

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Identifiers

PMID: 39265888
DOI: 10.1016/j.jare.2024.08.041
PMCID: PMC12225924

Genes

BDNF
CA1
IFT172

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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