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Article

Haploinsufficiency of intraflagellar transport protein 172 causes autism-like behavioral phenotypes in mice through BDNF.

Journal of advanced research - 1 Jul 2025

Zheng Nanxi, Luo Shilin, Zhang Xin, Hu Ling, Huang Muzhi, Li Mingyu, McCaig Colin, Ding Yu-Qiang, Lang Bing

Abstract excerpt

INTRODUCTION: Primary cilia are hair-like solitary organelles growing on most mammalian cells that play fundamental roles in embryonic patterning and organogenesis. Defective cilia often cause a suite of inherited diseases called ciliopathies with multifaceted manifestations. Intraflagellar transport (IFT), a bidirectional protein trafficking along the cilium, actively facilitates the formation and absorption of...

Topics

Animals
Haploinsufficiency
Brain-Derived Neurotrophic Factor
Mice
Autistic Disorder
Hippocampus
Phenotype
Behavior, Animal
Cilia
Signal Transduction
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Disease Models, Animal

Mice, Inbred C57BL

Source

Open in PubMed Open full text

Identifiers

PMID: 39265888
DOI: 10.1016/j.jare.2024.08.041
PMCID: PMC12225924

Genes

BDNF
CA1
IFT172

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-39265888-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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