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Article

Deletions of Cacna2d3 in parvalbumin-expressing neurons leads to autistic-like phenotypes in mice.

Neurochemistry international - 1 Oct 2023

Shao Wei, Zheng Hang, Zhu Jingwen, Li Wenhao, Li Yifan, Hu Wenjie, Zhang Juanjuan, Jing Liang, Wang Kai, Jiang Xiao

Abstract excerpt

Autism spectrum disorder (ASD) is a series of highly inherited neurodevelopmental disorders. Loss-of-function (LOF) mutations in the CACNA2D3 gene are associated with ASD. However, the underlying mechanism is unknown. Dysfunction of cortical interneurons (INs) is strongly implicated in ASD. Parvalbumin-expressing (PV) INs and somatostatin-expressing (SOM) INs are the two most subtypes. Here, we characterized a...

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PMID: 37419212
DOI: 10.1016/j.neuint.2023.105569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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