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Late onset and regional heterogeneity of synaptic deficits in cortical PV interneurons of <i> Shank3B <sup>−/−</sup> </i> mice

2023-11-23

Abstract excerpt

Epilepsy and epileptiform patterns of cortical activity are highly prevalent in autism spectrum disorders (ASDs), but the neural substrates and pathophysiological mechanisms underlying the onset of cortical dysfunction in ASD remains elusive. Reduced cortical expression of Parvalbumin (PV) has been widely observed in ASD mouse models and human postmortem studies, suggesting a crucial role of PV interneurons (PVINs...

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Literature Corpus work
0ad4ea7d-7629-53d5-a331-626734022aa7
DOI
10.1101/2023.11.23.568500
Open publication

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Late onset and regional heterogeneity of synaptic deficits in cortical PV interneurons of <i> Shank3B <sup>−/−</sup> </i> miceDOI 10.1101/2023.11.23.568500
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