Article
Pyramidal neurons form active, transient, multilayered circuits perturbed by autism-associated mutations at the inception of neocortex.
Cell - 27 Apr 2023
Munz Martin, Bharioke Arjun, Kosche Georg, Moreno-Juan Verónica, Brignall Alexandra, Rodrigues Tiago M, Graff-Meyer Alexandra, Ulmer Talia, Haeuselmann Stephanie, Pavlinic Dinko, Ledergerber Nicole, Gross-Scherf Brigitte, Rózsa Balázs, Krol Jacek, Picelli Simone, Cowan Cameron S, Roska Botond
Abstract excerpt
Cortical circuits are composed predominantly of pyramidal-to-pyramidal neuron connections, yet their assembly during embryonic development is not well understood. We show that mouse embryonic Rbp4-Cre cortical neurons, transcriptomically closest to layer 5 pyramidal neurons, display two phases of circuit assembly in vivo. At E14.5, they form a multi-layered circuit motif, composed of only embryonic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.