Article

Developmental and behavioral phenotypes in a new mouse model of DDX3X syndrome

2021-01-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Mutations in the X-linked gene DDX3X account for ~2% of intellectual disability in females, often co-morbid with behavioral problems, motor deficits, and brain malformations. DDX3X encodes an RNA helicase with emerging functions in corticogenesis and synaptogenesis. <h4>Methods</h4> We generated a Ddx3x haploinsufficient mouse ( Ddx3x +/− ) with construct validity for...

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Literature Corpus work: c3a897db-8437-505f-9cd8-8eea94e8f7ec
DOI: 10.1101/2021.01.22.427482

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