Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Behavioral and cerebellar transmission deficits in mice lacking the autism-linked gene islet brain-2.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Nov 2010

Giza Joanna, Urbanski Michael J, Prestori Francesca, Bandyopadhyay Bhaswati, Yam Annie, Friedrich Victor, Kelley Kevin, D'Angelo Egidio, Goldfarb Mitchell

Abstract excerpt

Deletion of the human SHANK3 gene near the terminus of chromosome 22q is associated with Phelan-McDermid syndrome and autism spectrum disorders. Nearly all such deletions also span the tightly linked IB2 gene. We show here that IB2 protein is broadly expressed in the brain and is highly enriched within postsynaptic densities. Experimental disruption of the IB2 gene in mice reduces AMPA and enhances NMDA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cerebellar Diseases
Share to Child Development Disorders, Pervasive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 22

Share to Cognition Disorders

Share to Mental Disorders

Share to Receptors, AMPA

Share to Receptors, N-Methyl-D-Aspartate

Share to Synaptic Transmission

Source

Open in PubMed Open full text

Identifiers

PMID: 21048139
DOI: 10.1523/JNEUROSCI.1161-10.2010
PMCID: PMC3200367

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Behavioral and cerebellar transmission deficits in mice lacking the autism-linked gene islet brain-2.PMID 21048139Read ↗

Autism-Associated Insertion Mutation (InsG) of Shank3 Exon 21 Causes Impaired Synaptic Transmission and Behavioral Deficits.Semantic proximity Read ↗

Cell-Type-Specific Shank2 Deletion in Mice Leads to Differential Synaptic and Behavioral Phenotypes.Semantic proximity Read ↗

ASTN2 in ASD and neurodevelopmental disorders.Semantic proximity Read ↗

Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3Semantic proximity Read ↗

BAIAP2 (IRSp53) as a Multi-Scale Brain-Disease Gene Across Synaptic Circuits and NeurodevelopmentSemantic proximity Read ↗

Behavioral regression in shank3Δex4-22 mice during early adulthood corresponds to cerebellar granule cell glutamatergic synaptic changesSemantic proximity Read ↗

Inherited and de novo SHANK2 variants associated with autism spectrum disorder impair neuronal morphogenesis and physiology.Semantic proximity Read ↗

Deletions in GRID2 lead to a recessive syndrome of cerebellar ataxia and tonic upgaze in humansSemantic proximity Read ↗

Mice lacking GRIP1/2 show increased social interactions and enhanced phosphorylation at GluA2-S880.Semantic proximity Read ↗

A new mouse allele of glutamate receptor delta 2 with cerebellar atrophy and progressive ataxia.Semantic proximity Read ↗

Adult restoration of Shank3 expression rescues selective autistic-like phenotypes.Semantic proximity Read ↗

Gain-of-function glutamate receptor interacting protein 1 variants alter GluA2 recycling and surface distribution in patients with autism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.