Article

Whole-brain clearing reveals region- and cell type-specific imbalances in inhibitory neurons in a mouse model for Kleefstra Syndrome

2025-09-16

Abstract excerpt

GABAergic inhibition is essential for balanced brain function and is frequently disrupted in neurodevelopmental disorders such as autism spectrum disorder (ASD). The inhibition is generated by a diverse population of GABAergic interneurons, whose composition and density differs throughout the brain. Here, we applied an unbiased whole-brain clearing and light-sheet imaging approach to systematically map the distrib...

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Literature Corpus work: 461e6bcc-f3df-520c-b717-7d8efa25aba5
DOI: 10.1101/2025.09.15.676416

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Whole-brain clearing reveals region- and cell type-specific imbalances in inhibitory neurons in a mouse model for Kleefstra SyndromeDOI 10.1101/2025.09.15.676416Read

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