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Isolated loss of the AUTS2 long isoform, brain-wide or targeted to Calbindin -lineage cells, generates a specific suite of brain, behavioral and molecular pathologies

2023-05-04

Abstract excerpt

Rearrangements within the AUTS2 region are associated with a rare syndromic disorder with intellectual disability, developmental delay and behavioral abnormalities as core features. In addition, smaller regional variants are linked to wide range of neuropsychiatric disorders, underscoring the gene’s essential role in brain development. Like many essential neurodevelopmental genes, AUTS2 is large and complex, gen...

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Literature Corpus work: 147dc903-7113-5fce-8de7-00ad384fe33c
DOI: 10.1101/2023.05.04.539486

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Isolated loss of the AUTS2 long isoform, brain-wide or targeted to <i>Calbindin</i> -lineage cells, generates a specific suite of brain, behavioral and molecular pathologies

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