Article

Mapping the Peptide Interaction Fingerprint of the Behçet’s disease associated HLA-B*51

2025-12-01

Abstract excerpt

<h4>ABSTRACT</h4> The strongest genetic risk factor for Behçet’s disease, a relapsing inflammatory disorder marked by recurrent mucocutaneous ulcers and uveitis, is an allele of the class I major histocompatibility complex (MHC-I) molecule, which presents intracellular peptides to CD8 + T cells. The molecular mechanisms linking the peptide preferences of this allele (HLA-B*51:01) to dysregulated immunity remain...

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Literature Corpus work: 74ad7a3d-da62-5516-a65a-2716ffd84995
DOI: 10.1101/2025.11.26.690622

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