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Article

A structure-guided approach to predict MHC-I restriction of T cell receptors for public antigens.

Structure (London, England : 1993) - 4 Sept 2025

Gupta Sagar, Sgourakis Nikolaos G

Abstract excerpt

Peptides presented by major histocompatibility complex class I (MHC-I) proteins provide biomarkers for therapeutic targeting using T cell receptors (TCRs), TCR-mimicking antibodies (TMAs), or other engineered protein binders. Despite the extreme sequence diversity of the human leukocyte antigen (HLA, the human MHC), a given TCR or TMA is restricted to recognize epitopic peptides in the context of a limited set of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40683256
DOI: 10.1016/j.str.2025.06.011
PMCID: PMC12313147

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