Article
A practical guide to structure-based prediction of MHC-binding peptides.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2007
Ranganathan Shoba, Tong Joo Chuan
Abstract excerpt
The binding of bound peptide ligands to major histocompatibility complex (MHC) molecules plays a key role in the activation of normal immune responses and is an intricate theoretical problem that remains unsolved. Geometric and energetic complementarities between an MHC molecule and its corresponding bound peptide ligand are critical in determining the stability of the complex. In this context, the introduction...
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