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Article

Compression of functional space in HLA-A sequence diversity.

Human immunology - 1 Jul 2003

Zhao Bing, Png Adrian Eak H, Ren Ee Chee, Kolatkar Prasanna R, Mathura Venkatarajan Subramaniam, Sakharkar Meena Kishore, Kangueane Pandjassarame

Abstract excerpt

The major histocompatibility complex (MHC) is highly polymorphic and more than 1500 human MHC alleles are known to date. These alleles do not bind to a given peptide with identical affinity. Although MHC alleles are functionally related, it is difficult to quantify the functional variation between them. Three-dimensional structures of known MHC-peptide (MHCp) complexes suggest that specific peptide residues bind...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12826374
DOI: 10.1016/s0198-8859(03)00078-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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