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Article

Sequence-structure-function relationships in class I MHC: A local frustration perspective.

PloS one - 1 Jan 2020

Serçinoğlu Onur, Ozbek Pemra

Abstract excerpt

Class I Major Histocompatibility Complex (MHC) binds short antigenic peptides with the help of Peptide Loading Complex (PLC), and presents them to T-cell Receptors (TCRs) of cytotoxic T-cells and Killer-cell Immunglobulin-like Receptors (KIRs) of Natural Killer (NK) cells. With more than 10000 alleles, human MHC (Human Leukocyte Antigen, HLA) is the most polymorphic protein in humans. This allelic diversity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32421728
DOI: 10.1371/journal.pone.0232849
PMCID: PMC7233585

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