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Article

Machine learning reveals a non-canonical mode of peptide binding to MHC class II molecules.

Immunology - 1 Oct 2017

Andreatta Massimo, Jurtz Vanessa I, Kaever Thomas, Sette Alessandro, Peters Bjoern, Nielsen Morten

Abstract excerpt

MHC class II molecules play a fundamental role in the cellular immune system: they load short peptide fragments derived from extracellular proteins and present them on the cell surface. It is currently thought that the peptide binds lying more or less flat in the MHC groove, with a fixed distance of nine amino acids between the first and last residue in contact with the MHCII. While confirming that the great...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28542831
DOI: 10.1111/imm.12763
PMCID: PMC5588850

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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