Article

Dietary glutamine supplementation alleviates age-related cardiac dysfunction by reducing elevated H3K27me3

2025-05-19

Abstract excerpt

<h4>Background</h4> Changes to the epigenetic landscape play an important role in cardiovascular aging, where alterations in histone modifications influence gene expression by regulating DNA accessibility and chromatin structure. Our investigation into epigenetic changes during myocardial aging revealed that the repressive epigenetic mark H3K27me3 is significantly upregulated in aged mice and humans. This increas...

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Literature Corpus work: f8897e8d-34be-5d85-b900-72814650bf30
DOI: 10.1101/2025.05.16.654624

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