Article

Loss of Tip60-dependent H2A.Z acetylation reprograms cardiomyocyte identity toward a regenerative state

2024-01-13

Abstract excerpt

<h4>ABSTRACT</h4> Approaches to regenerate cardiomyocytes (CMs) after cardiac injury have been insufficient. Toward this end we are targeting the acetyltransferase Tip60, encoded by the Kat5 gene, based on the rationale that its pleiotropic functions block CM proliferation at multiple checkpoints. We previously reported that genetic depletion or pharmacological inhibition of Tip60 in mice after myocardial infarc...

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Literature Corpus work: f3b71c94-2fb2-5ba8-a45c-632c1738d247
DOI: 10.1101/2024.01.11.575312

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Loss of Tip60-dependent H2A.Z acetylation reprograms cardiomyocyte identity toward a regenerative stateDOI 10.1101/2024.01.11.575312Read

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