Article

Humanin analogue promotes metabolic reprogramming to protect the ischemic heart

2026-06-22

Abstract excerpt

<h4>Background</h4> Myocardial ischemia drives adverse cardiac remodeling, metabolic inflexibility, and progression to heart failure. Mitochondrial dysfunction and impaired substrate utilization contribute to cardiomyocyte death and fibrosis, particularly with aging. Humanin (HNG), a mitochondria-derived peptide, has been shown to reduce acute ischemic injury, but its role in chronic ischemia and cardiac remodeli...

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Literature Corpus work: a34ab1e4-765d-505c-94a7-5ac2433fd52f
DOI: 10.64898/2026.06.16.732776

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