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Article

Targeting muscle-enriched long non-coding RNA H19 reverses pathological cardiac hypertrophy

3 Jun 2020

Abstract excerpt

AIMS: Pathological cardiac remodelling and subsequent heart failure represents an unmet clinical need. Long non-coding RNAs (lncRNAs) are emerging as crucial molecular orchestrators of disease processes, including that of heart diseases. Here, we report on the powerful therapeutic potential of the conserved lncRNA H19 in the treatment of pathological cardiac hypertrophy. METHOD AND RESULTS: Pressure...

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PMID: 32657324
DOI: 10.1093/eurheartj/ehaa519

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