Article

High-resolution MHC haplotyping with long-read hybrid capture

2026-03-30

Abstract excerpt

The major histocompatibility complex (MHC) is among the most polymorphic and difficult-to-genotype regions of the human genome. Accurate haplotyping of its antigen-presenting HLA genes is critical for transplantation, pharmacogenomics, and disease-risk prediction. Short reads struggle to resolve MHC haplotypes, and although long-read sequencing offers a solution, its adoption in tissue typing has been constrained...

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Literature Corpus work: f8843d52-4f68-5bdd-976e-584b5e9ff4d3
DOI: 10.64898/2026.03.27.26349549

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