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Article

Ultra-long sequencing for contiguous haplotype resolution of the human immunoglobulin heavy chain locus

2024-12-17

Abstract excerpt

Genetic diversity within the human immunoglobulin heavy chain (IGH) locus influences the expressed antibody repertoire and susceptibility to infectious and autoimmune diseases. However, repetitive sequences and complex structural variation pose significant challenges for large-scale characterization. Here, we introduce a method using Oxford Nanopore ultra-long sequencing and adaptive sampling, coupled with a bioin...

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Literature Corpus work
3a949d0b-d3f0-544e-bc27-f16ef3add7fe
DOI
10.1101/2024.12.14.628445
Open publication

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Ultra-long sequencing for contiguous haplotype resolution of the human immunoglobulin heavy chain locusDOI 10.1101/2024.12.14.628445
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