Article
SpecHLA enables full-resolution HLA typing from sequencing data.
Cell reports methods - 25 Sept 2023
Wang Shuai, Wang Mengyao, Chen Lingxi, Pan Guangze, Wang Yanfei, Li Shuai Cheng
Abstract excerpt
Reconstructing diploid sequences of human leukocyte antigen (HLA) genes, i.e., full-resolution HLA typing, from sequencing data is challenging. The high homogeneity across HLA genes and the high heterogeneity within HLA alleles complicate the identification of genomic source loci for sequencing reads. Here, we present SpecHLA, which utilizes fine-tuned reads binning and local assembly to achieve accurate...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.